Osteoarthritis is a long-term disease that occurs when the cartilage that acts as padding between the joints breaks down. This causes the bones to rub together, causing pain, swelling, stiffness, and decreased mobility. The knee is one of the most common joints affected by osteoarthritis.
Common causes of osteoarthritis of the knee include old age, increased body weight, heredity, gender (osteoarthritis is more common in women), or repetitive stress injuries.
The study drug (GLPG1972) in the Roccella study could prevent or decrease cartilage destruction in the knee to treat osteoarthritis.